Quatrefolic® the InnovACTIVE Folate , is the glucosamine salt of the 5-methyltetrahydrofolate (5-MTHF), the metabolic active form of folate, available for its biological action, ubiquitous in all body cells and the only form of folate  that crosses the blood-brain barrier directly.

Quatrefolic® maximizes the benefit of folate supplementation, overcoming the potential inability to benefit of both folic acid and 5-MTHF calcium salt supplementation for:

  • the partial inability of some people to convert folic acid to 5-MTHF and the related safety risk of it accumulation in the blood
  • the related poor solubility and low stability of 5-MTHF calcium salt formulation

Quatrefolic® advantages:

  • Highly bioavailable: Quatrefolic has been shown higher bioavailability compared to calcium salt derivatives and folic acid
  • Soluble: Quatrefolic is 100 times more soluble in water than 5-methyltetrahydrofolate calcium salt
  • Stable: Quatrefolic does not need specific conditions of storage or handling
  • Safe: Quatrefolic does not need any metabolization and does not expose cells to unmetabolized folic acid
  • Formulation flexibility: Quatrefolic can be easily combined with other ingredients and excipients
  • For vegetarian consumers: Kosher, Halal
  • Strong IP: US 7,947,662, EP 2245032 and  EP 2254890 that covers applications and combinations with other actives.