Gnosis is truthfully proud to announce a great confirmation and success obtained from Superesse®, the enriched natural yeast with S-Adenosylmethionine (SAMe) that states the importance of SAMe (Adomet®) as nutritional driving compound, and the leading role of Gnosis in developing products based on S-Adenosylmethionine.

The Japanese Ministry of Health, Labour and Welfare (MHLW) has granted an health claim to Gnosis’ SupereSSe®. The grant of the health claim, which refers to “Improvement for the joint wrongness”, has a peerless importance and is having rather big reaction from Japanese market.

This achievement is very impressive especially because, Japan is a thought leader in the manufacture and use of “Foods with Health Claims” – the preferred term for dietary supplements and natural nutraceuticals in Japan.

The health-conscious Japanese have long embraced the benefits from nutraceuticals, and the country ranked third in per capita spend on nutraceuticals in 2014 according to World Health Organization (WHO) data, while others place Japan as the second largest individual consumer of nutraceuticals (behind the U.S.).

“For regulatory purposes, nutraceuticals in Japan are heavily regulated so achieving an health claim in Japan is extremely hard” said Paolo Malesani, Commercial director of Gnosis Group – “but that confirm the SupereSSe® outstanding nutritional value has been recognized for the improvement of joint wrongness”.


The scientific efficacy of the SAMe SupereSSe® has been proven through a human clinical study – placebo-controlled double-blind randomized clinical trial – to reduce knee discomfort. The study has been published on Japan Pharmacology & Therapeutics in 2015.

(Yamanaka N. et al. “The effects of SAM-e yeast to improve the discomfort of knee in healthy adults” Jpn Pharmacol Ther 2015; 43:549-59)

For more information contact: