The importance of the consumption of folate to support the body’s well-being is now widely recognized and folate definitely represents one of the most common nutritional ingredients used during all stages of life.
Very recently ConsumerLab has published a new report titled “B Vitamin Supplements and Energy Drinks (Including B Complexes, Niacin, B-6, B-12, Biotin, Thiamin, and Folate)” where several finished dietary supplements, commercialized in the US market and containing the (6S)-5-methyltetrahydrofolate (5-MTHF) – the biological active form of folate – or folic acid, have been tested.
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The report mentions the rational use of reduced folate and describes why they are suggested for people with a gene polymorphism of the enzyme MTHFR (methyltetrahydrofolate reductase) that drives to an impairment in the metabolization of folic acid and folate from food or supplements to (6S)-5MTHF also named L-methylfolate, the active form of folate in the body. According to the data shared by the report, roughly 33% of Americans carry one copy of a common MTHFR gene mutation (C677T). People with two C677T mutations is about 11% of Americans.
Aberrant folate metabolism has adverse effects on human health, including increased risk for birth defects, cancer, cardiovascular disease , end-stage renal disease, diabetic neuropathy, and CNS disorders such as depression and cognitive impairment (Tsang BL et al. Am. J. Clin. Nutr. 2015).
Supplements with (6S)-5MTHF, alone or in combination, have been positively tested among the other. They have been promoted by the manufacturer for use by people with this common genetic defect.
Among reduced folate, Quatrefolic®, the Gnosis’ proprietary innovActive folate made up of the glucosamine salt of (6S)-5-MTHF, is even more recognized as the folate of reference in the US market, as a direct source of the 5-MTHF that doesn’t need to be metabolized and can enter immediately folate-dependent pathways. It has established itself as the benchmark for the whole industry of folate derivatives.
The independent prove of the stability of Quatrefolic® in supplements, together with the already known advantages of this recommended reduced folate demonstrate again like it is a winning mix of efficacy, innovation and safety.
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