St. Charles, MO USA – Stratum Nutrition announces that new research demonstrating the clinical benefit of ACTAZIN™, a green kiwifruit ingredient produced by Anagenix, Ltd for digestive health, has recently been published in the journal Nutrition Research (DOI:

This randomized, double-blind, placebo-controlled study displayed clinically significant benefits in a healthy cohort.

Gastrointestinal issues, including constipation, are common conditions worldwide in adults and children, which can severely affect the individual’s quality of life and feeling of general wellbeing. Gastrointestinal issues are regarded by many clinicians to be an underlying cause of a variety of illnesses.

The study evaluated 19 healthy adult volunteers and 9 volunteers with complaints of functional constipation for stool frequency and quality along with a daily diary for quality of life. The results of this clinical trial demonstrated a statistically significant increase (P < 0.014) in mean daily bowel movements (healthy cohort) following one month of ACTAZIN (2400 mg/day) consumption. The magnitude of effect corresponded to an approximate increase of 1 bowel movement per week, which is regarded as a clinically meaningful effect by the FDA. A lower daily dose of ACTAZIN (600 mg) produced a numerically equivalent result, just missing statistical significance (P < 0.06) across the entire group, but was statistically significant in the responder sub-group (P < 0.005; n = 14). This suggests that a low dose (600 mg) of ACTAZIN alone could help maintain a healthy digestive system.

ACTAZIN is a powdered ingredient derived from whole New Zealand green (Actinidia deliciosa ‘Hayward’) kiwifruit from which the skin and seeds are removed and the remaining flesh cold processed for use in dietary supplements for the support of digestive health. Contributing to the modes of action for ACTAZIN include the presence of bioactive substances including fiber, polyphenolics, and the kiwifruit-specific enzyme, actinidin. An additional mode of action of ACTAZIN is possibly due to its ability to serve as a substrate for endogenous gut bacteria. For more information on ACTAZIN, please visit


Videos with clinical principles explaining findings and significance available:

About Stratum Nutrition
Stratum Nutrition, a Novus International company, is a specialty health ingredient supplier to the supplement and pet food industries. Stratum offers a portfolio of branded, value-added ingredients developed in collaboration with global partnerships such as Anagenix, based on consumer need, and supported by science. Stratum specializes in condition-specific categories which include digestive, immune, and structural health to offer full solutions for human and companion animal nutrition. Leveraging the Novus core competencies in nutritional research and innovation, these ingredients are innovative, safe, and substantiated by clinical research.

Ansell J et al (2015). Kiwifruit derived supplements increase stool frequency in healthy adults: a randomized, double-blind, placebo-controlled study. Nutrition Research. DOI information: 10.1016/j.nutres.2015.04.005