The natural sexual enhancer for Men

Enostim™ is a unique and proprietary formulation of active ingredients, apple and grape polyphenols, enriched with saffron. Enostim has been specifically developed to offer a natural and safe solution for erectile dysfunction.

3 synergistic benefits:

  • Vasodilation enhancer: The Nitric Oxide (NO) pathway is the cornerstone of the vasodilation mechanism allowing penile erection. In vitro1 and ex vivo2 studies show that Nexira’s proprietary formulation activates eNOS (endothelial Nitric Oxide synthase) by the production of NO which conducts to an increase of vasodilation up to 50%.
  • Saffron benefits: Since antiquity, saffron (flower stigmas from Crocus sativus) has been used in traditional medicine. It was already consumed as an aphrodisiac by ancient Persians and Egyptians. More recently, saffron’s ability to prevent erectile dysfunction has been demonstrated in several clinical studies3,4.
  • Nitric Oxide protection: Nitric oxide has a short lifespan and is easily degraded by superoxide free radical. As shown in an in vivo study7, the antioxidant molecules in EnoSTIM™ demonstrated the potential to specifically protect NO by decreasing oxidative stress by 74%.
  • Recommended dosage: 300-600 mg / day
(1) Effect of NPF on the activation of eNOs through the phosphorylation of “Serine 1177” from endothelial cells (HUVECs) as measured by flow cytometry. 2008.
(2) NPF stimulate endothelial-dependent vasodilation by nitric oxide synthesis. Ex vivo study on rat aorta. 2004.
(3) Shamsa A, et al. Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study. Phytomedicine. 2009 Aug;16(8):690-3.
(4) Cai T, et al. An improvement in sexual function is related to better quality of life, regardless of urinary function improvement: results from the IDIProst® Gold Study. Arch Ital Urol Androl. 2013 Dec 31;85(4):184-9.
(5) The effects of NPF, a formulation containing grape and apple extracts and its effect on the production of peroxinitrites in hamsters subjected to aerobic physical activity. 2004